The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11840519 B1

Date of Patent:

Dec. 12, 2023

Filed:

Jul. 27, 2020

Process for the synthesis of the sodium salt of 4-[[(1r)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)-phenyl]methyl]-3,6-dihydro-4-methyl-2.6-dioxo-1(2h)-pyrimidinyl]-1-phenylethyl]amino]-butanoic acid (elagolix sodium salt) and intermediates of said process

Applicant:

Industriale Chimica S.r.l., Milan, IT;

Inventors:

Roberto Lenna, S. Giorgio su Legnano, IT;

Andrea Fasana, Nesso, IT;

Jerry Ortiz, Milan, IT;

Assignee:

INDUSTRIALE CHIMICA S.R.L., Milan, IT;

Attorney:

Troutman Pepper Hamilton Sanders LLP (Rochester)

Primary Examiner:

Deepak R Rao

Int. Cl.

CPC ...

C07D 239/553 (2006.01);

U.S. Cl.

CPC ...

C07D 239/553 (2013.01);

Abstract

The present invention to a process for the preparation of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-amino]-butanoic acid, compound also known as Elagolix sodium salt, having the formula (I) reported below:

Find Patent Forward Citations