The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2023
Filed:
May. 17, 2018
Idorsia Pharmaceuticals Ltd, Allschwil, CH;
Christoph Boss, Allschwil, CH;
Olivier Corminboeuf, Allschwil, CH;
Heinz Fretz, Gunten, CH;
Isabelle Lyothier, Allschwil, CH;
Davide Pozzi, Allschwil, CH;
Sylvia Richard-Bildstein, Allschwil, CH;
Hervé Siendt, Allschwil, CH;
Thierry Sifferlen, Allschwil, CH;
Idorsia Pharmaceuticals Ltd, Allschwil, CH;
Abstract
The present invention relates to pyrimidine derivatives of formula (I) wherein (R), R, R, R, R, Rand Arare as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.