The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Dec. 29, 2016
Applicant:
Celgene Corporation, Summit, NJ (US);
Inventors:
Bitao Liang, Closter, NJ (US);
Xiaohua Lu, Monmouth Junction, NJ (US);
Wei Liu, Bridgewater, NJ (US);
Kathy E. Karasciewicz-Mendez, Hillsborough, NJ (US);
Christopher Wiwi, Basking Ridge, NJ (US);
Kruti Shah, Piscataway, NJ (US);
Assignee:
CELGENE CORPORATION, Summit, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 39/00 (2006.01); A61K 35/17 (2015.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C12N 2501/2304 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/2315 (2013.01);
Abstract
Provided herein are methods of generating T cells, e.g., cytotoxic T lymphocytes starting from peripheral blood mononuclear cells without a separate step of generating and isolating antigen-presenting cells, and with a single round of antigen stimulation. Also provided herein are methods of using said cytotoxic T lymphocytes, for example, to treat cancer and/or viral infection.