The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Oct. 04, 2019
Applicant:
University of Southern California, Los Angeles, CA (US);
Inventors:
Yong Zhang, Los Angeles, CA (US);
Zhefu Dai, Los Angeles, CA (US);
Xiao-Nan Zhang, Los Angeles, CA (US);
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 19/20 (2006.01); A61K 31/7076 (2006.01); C12P 19/28 (2006.01);
U.S. Cl.
CPC ...
C07H 19/20 (2013.01); A61K 31/7076 (2013.01); C12P 19/28 (2013.01);
Abstract
This disclosure provides a method of synthesis of 4'-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4′-thioribose NAD+ and compounds related thereto.