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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11834432 B1

PDFFull Text
Date of Patent:
Dec. 05, 2023

Filed:

Feb. 17, 2017

Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof

Applicant:

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;

Inventors:

Ao Zhang, Shanghai, CN;

Meiyu Geng, Shanghai, CN;

Li Xing, Shanghai, CN;

Jing Ai, Shanghai, CN;

Zilan Song, Shanghai, CN;

Xia Peng, Shanghai, CN;

Wangting Gu, Shanghai, CN;

Jian Ding, Shanghai, CN;

Assignee:

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;

Attorney:

Panitch Schwarze Belisario & Nadel LLP

Primary Examiner:

Brenda L Coleman

Int. Cl.
CPC ...
C07D 213/75 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61P 35/00 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4433 (2006.01); A61K 31/4409 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/5355 (2006.01); A61K 31/5377 (2006.01); A61K 31/4545 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 35/00 (2018.01); C07D 213/75 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity.

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