The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 05, 2023

Filed:

Nov. 27, 2019
Applicants:

Board of Trustees of Southern Illinois University, Carbondale, IL (US);

Vanderbilt University, Nashville, TN (US);

Inventors:

Boyd M. Goodson, Carbondale, IL (US);

Eduard Y. Chekmenev, Troy, MI (US);

Bryce E. Kidd, Carbondale, IL (US);

Jamil A. Mashni, Carbondale, IL (US);

Miranda Limbach, Creal Springs, IL (US);

Yuqing Hou, Carbondale, IL (US);

Fan Shi, Houston, TX (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 233/60 (2006.01); G01R 33/28 (2006.01); C07D 401/06 (2006.01); C07D 241/12 (2006.01); C07D 213/63 (2006.01); C07F 9/6506 (2006.01); B01J 31/12 (2006.01); C07D 213/46 (2006.01); G01R 33/46 (2006.01);
U.S. Cl.
CPC ...
C07D 233/60 (2013.01); B01J 31/12 (2013.01); C07D 213/46 (2013.01); C07D 213/63 (2013.01); C07D 241/12 (2013.01); C07D 401/06 (2013.01); C07F 9/6506 (2013.01); G01R 33/282 (2013.01); B01J 2531/827 (2013.01); G01R 33/46 (2013.01);
Abstract

The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.


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