The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Oct. 18, 2021
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Jolanta Grembecka, Ann Arbor, MI (US);
Szymon Klossowski, Ann Arbor, MI (US);
Jing Deng, Ann Arbor, MI (US);
Tomasz Cierpicki, Ann Arbor, MI (US);
Hao Li, Ann Arbor, MI (US);
Hongzhi Miao, Ann Arbor, MI (US);
Trupta Purohit, Ann Arbor, MI (US);
EunGi Kim, Ann Arbor, MI (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/4545 (2006.01); A61K 47/64 (2017.01); A61K 9/00 (2006.01); A61K 31/454 (2006.01); A61K 38/45 (2006.01); A61P 35/02 (2006.01); A61K 47/54 (2017.01); A61K 31/404 (2006.01); C07D 209/24 (2006.01);
U.S. Cl.
CPC ...
A61K 47/64 (2017.08); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/404 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 38/45 (2013.01); A61K 47/545 (2017.08); A61K 47/556 (2017.08); A61P 35/02 (2018.01); C07D 209/24 (2013.01); C07D 471/04 (2013.01); C12Y 203/02 (2013.01);
Abstract
Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.