The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Mar. 27, 2021
Uppthera, Incheon, KR;
Si Woo Choi, Incheon, KR;
Soo Hee Ryu, Incheon, KR;
Ji Hoon Ryu, Seoul, KR;
San Ha Son, Incheon, KR;
Hwa Jin Lee, Incheon, KR;
Seong Hoon Kim, Incheon, KR;
Boas Nam, Incheon, KR;
Im Suk Min, Gyeonggi-do, KR;
Hye Guk Ryu, Incheon, KR;
Keum Young Kang, Incheon, KR;
UPPTHERA, INC., Incheon, KR;
Abstract
The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.