The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
Oct. 23, 2018
Applicant:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Inventors:
Shinsuke Ito, Tokyo, JP;
Elena Aikawa, Chestnut Hill, MA (US);
Masanori Aikawa, Chestnut Hill, MA (US);
Assignee:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 47/65 (2017.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1741 (2013.01); A61K 47/65 (2017.08); G01N 33/6803 (2013.01);
Abstract
Sortilin is a sorting receptor that directs target proteins to the secretary or endocytic compartments of cells that is found in both extracellular vesicles and cells. Provided herein are methods and compositions for decreasing or inhibiting trafficking of sortilin to an extracellular vesicle, for example by inhibiting the formation of intermolecular sortilin dimers.