The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2023
Filed:
May. 13, 2021
Applicant:
Xeris Pharmaceuticals, Inc., Chicago, IL (US);
Inventors:
Steven J. Prestrelski, San Diego, CA (US);
Michael A. Sandoval, Beaverton, OR (US);
Brian R. Sloat, Austin, TX (US);
Assignee:
Xeris Pharmaceuticals, Inc., Chicago, IL (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/197 (2006.01); A61K 31/4045 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 47/20 (2006.01); A61K 47/14 (2017.01); A61K 47/16 (2006.01); A61K 47/26 (2006.01); A61K 47/28 (2006.01); A61K 31/5513 (2006.01); A61K 47/22 (2006.01); A61P 25/14 (2006.01); A61P 25/22 (2006.01); A61P 25/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5513 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 31/197 (2013.01); A61K 31/4045 (2013.01); A61K 47/14 (2013.01); A61K 47/16 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/28 (2013.01); A61P 25/08 (2018.01); A61P 25/14 (2018.01); A61P 25/22 (2018.01);
Abstract
Embodiments of the invention are directed to formulations that provide a solution to the problem of small molecule (e.g., diazepam) precipitation at the injection site when administered as a highly-concentrated formulation. In certain aspects the formulations include at least one surfactant in a non-aqueous formulation, which prevents small molecule precipitation and improves the bioavailability of the drug by enhancing absorption into the systemic circulation.