The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 05, 2023

Filed:

Sep. 20, 2018
Applicant:

Jubilant Epipad Llc, Yardley, PA (US);

Inventors:

Gurulingappa Hallur, Bangalore, IN;

Athisayamani Jeyaraj Duraiswamy, Bangalore, IN;

Buchi Reddy Purra, Bangalore, IN;

N. V. S. K. Rao, Bangalore, IN;

Sridharan Rajagopal, Bangalore, IN;

Assignee:

JUBILANT EPIPAD LLC, Yardley, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/06 (2006.01); C07D 498/16 (2006.01); A61K 31/5365 (2006.01); A61P 1/00 (2006.01); A61P 11/06 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61K 31/5383 (2006.01); A61K 31/4985 (2006.01); A61K 31/553 (2006.01); A61K 45/06 (2006.01); C07D 487/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5383 (2013.01); A61K 31/4985 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 487/06 (2013.01); C07D 498/06 (2013.01);
Abstract

Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.


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