The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 05, 2023

Filed:

Sep. 29, 2022
Applicant:

Nerviano Medical Sciences S.r.l., Nerviano, IT;

Inventors:

Simona Bindi, Milan, IT;

Davide Carenzi, Travedona Monate, IT;

Ilaria Motto, Nerviano, IT;

Maurizio Pulici, Caponago, IT;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 487/04 (2006.01); C07D 513/04 (2006.01); A61P 37/00 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61K 31/4355 (2006.01); A61K 31/4365 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/4355 (2013.01); A61K 31/4365 (2013.01); A61P 25/28 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C07D 487/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.


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