The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 05, 2023

Filed:

Jan. 08, 2021
Applicants:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Vanquish Oncology, Inc., Champaign, IL (US);

Inventors:

Paul J. Hergenrother, Champaign, IL (US);

Rachel C. Botham, Champaign, IL (US);

Timothy M. Fan, Mahomet, IL (US);

Mark J. Gilbert, Seattle, WA (US);

Michael K. Handley, Windsor, CO (US);

Howard S. Roth, Champaign, IL (US);

Theodore M. Tarasow, San Ramon, CA (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/495 (2006.01); A61K 33/243 (2019.01); A61K 9/08 (2006.01); A61K 31/138 (2006.01); A61K 31/282 (2006.01); A61K 31/337 (2006.01); A61K 31/496 (2006.01); A61K 31/553 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 33/24 (2019.01); A61K 38/05 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/495 (2013.01); A61K 9/008 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2059 (2013.01); A61K 9/4858 (2013.01); A61K 31/138 (2013.01); A61K 31/282 (2013.01); A61K 31/337 (2013.01); A61K 31/496 (2013.01); A61K 31/553 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 33/24 (2013.01); A61K 33/243 (2019.01); A61K 38/05 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01);
Abstract

The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.


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