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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11827937 B1

PDFFull Text
Date of Patent:
Nov. 28, 2023

Filed:

Dec. 27, 2019

Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof

Applicant:

Celera Corporation, San Juan Capistrano, CA (US);

Inventor:

Dov Shiffman, Palo Alto, CA (US);

Assignee:

Celera Corporation, San Juan Capistrano, CA (US);

Attorney:

Celera Corporation

Primary Examiner:

Jeanine A Goldberg

Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6883 (2018.01); G16B 20/50 (2019.01); G16B 20/30 (2019.01); G16B 20/20 (2019.01); G16B 25/20 (2019.01); A61K 31/22 (2006.01); A61K 31/366 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/405 (2006.01); A61K 31/455 (2006.01); A61K 31/505 (2006.01); G16B 20/00 (2019.01); G16B 25/00 (2019.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/22 (2013.01); A61K 31/366 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/405 (2013.01); A61K 31/455 (2013.01); A61K 31/505 (2013.01); G16B 20/20 (2019.02); G16B 20/30 (2019.02); G16B 20/50 (2019.02); G16B 25/20 (2019.02); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/172 (2013.01); G16B 20/00 (2019.02); G16B 25/00 (2019.02);
Abstract

The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.

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