The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2023
Filed:
Jul. 14, 2020
Applicant:
Sangamo Therapeutics, Inc., Brisbane, CA (US);
Inventors:
Jeffrey C. Miller, Brisbane, CA (US);
Edward J. Rebar, Brisbane, CA (US);
Assignee:
Sangamo Therapeutics, Inc., Brisbane, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/90 (2006.01); C12N 9/22 (2006.01); C12N 9/14 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C12N 9/14 (2013.01); C12N 9/22 (2013.01); A61K 38/00 (2013.01); C07K 2319/81 (2013.01);
Abstract
Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.