The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2023
Filed:
Mar. 27, 2018
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
James L. Riley, Downingtown, PA (US);
Gavin Ellis, Philadelphia, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 15/86 (2006.01); A61P 3/10 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2827 (2013.01); A61K 35/17 (2013.01); A61P 3/10 (2018.01); C07K 14/7051 (2013.01); C07K 14/70503 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 16/2833 (2013.01); C12N 5/0637 (2013.01); C12N 15/86 (2013.01); A61K 2039/5156 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/74 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15043 (2013.01); C12N 2830/00 (2013.01);
Abstract
The present invention includes compositions and methods for an HLA-A2 specific chimeric antigen receptor (CAR). In certain embodiments the HLA-A2 specific CAR is expressed on a T regulatory cell. In certain embodiments, the HLA-A2 specific CAR protects transplanted tissue from rejection.