The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2023
Filed:
Apr. 20, 2021
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Cristina Abrahams, Burlingame, CA (US);
Edward Bowman, Redwood City, CA (US);
Xiaofan Li, Belmont, CA (US);
Songnian Lin, Holmdel, NJ (US);
Willy Solis, San Mateo, CA (US);
Ryan Stafford, Foster City, CA (US);
Aarron Willingham, Mountain View, CA (US);
Alice Yam, Belmont, CA (US);
Junhao Yang, Milpitas, CA (US);
Gang Yin, South San Francisco, CA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγdimer over binding the IL-2 receptor αβγtrimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.