The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 28, 2023

Filed:

Oct. 22, 2021
Applicant:

Ildong Pharmaceutical Co., Ltd., Seoul, KR;

Inventors:

Myongjae Lee, Hwaseong-si, KR;

Changmok Oh, Hwaseong-si, KR;

Dami Lim, Hwaseong-si, KR;

Kyeong-A Kim, Hwaseong-si, KR;

Seolhee Lee, Hwaseong-si, KR;

Ilji Jeong, Hwaseong-si, KR;

Jaeeun Ryu, Hwaseong-si, KR;

Jooyun Lee, Hwaseong-si, KR;

Yearin Jun, Hwaseong-si, KR;

Jinsun Kwon, Hwaseong-si, KR;

Te-ik Sohn, Hwaseong-si, KR;

Gunhee Kim, Hwaseong-si, KR;

Jungho Kim, Hwaseong-si, KR;

Jongmin Yoon, Hwaseong-si, KR;

Jin Hee Lee, Hwaseong-si, KR;

Hongchul Yoon, Hwaseong-si, KR;

Jung Woo Lee, Hwaseong-si, KR;

Joontae Park, Gyeonggi-do, KR;

Kyung Mi An, Gyeonggi-do, KR;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present disclosure provides CFTR modulator and phosphodiesterase 4 (PDE4) inhibitor compounds of the formula (Ia): and compositions including said compounds. The compounds can provide functionality for modulating CFTR, methods for treating an eye disease or disorder, and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4 in a biological system or biological sample, for treating an inflammatory disease or disorder, and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.


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