The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 28, 2023

Filed:

Aug. 02, 2018
Applicant:

The University of Chicago, Chicago, IL (US);

Inventors:

Wenbin Lin, Chicago, IL (US);

Kaiyuan Ni, Chicago, IL (US);

Guangxu Lan, Chicago, IL (US);

Assignee:

The University of Chicago, Chicago, IL (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 41/00 (2020.01); A61P 35/00 (2006.01); A61K 33/243 (2019.01); A61K 45/06 (2006.01); A61K 47/34 (2017.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0071 (2013.01); A61K 33/243 (2019.01); A61K 41/0057 (2013.01); A61K 45/06 (2013.01); A61K 47/34 (2013.01); A61N 5/10 (2013.01); A61P 35/00 (2018.01);
Abstract

Metal-organic layers (MOLs) and metal-organic nanoplates (MOPs) comprising photosensitizers are described. The MOLs and MOPs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the MOL or MOP. Also described are methods of using MOLs and MOPs in photodynamic therapy, X-ray induced photodynamic therapy (X-PDT), radiotherapy (RT), radiodynamic therapy, or in radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator.


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