The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2023
Filed:
Nov. 09, 2017
The Board of Regents of the University of Texas System, Austin, TX (US);
Pulmotect, Inc., Houston, TX (US);
The Texas A&m University System, College Station, TX (US);
Burton F. Dickey, Houston, TX (US);
Michael J. Tuvim, Houston, TX (US);
Scott E. Evans, Bellaire, TX (US);
Magnus Hook, College Station, TX (US);
David P. Huston, College Station, TX (US);
Margarita Martinez-Moczygemba, College Station, TX (US);
Brenton Scott, Houston, TX (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Abstract
Embodiments are directed to methods and compositions for modulating an immune response. In certain aspects the immune response is a type I hypersensitivity response. In particular aspects the subject has allergic asthma or allergic rhinitis. Using a conventional experimental asthma mouse model (BALB/c), the inventors demonstrate that aerosol administration of TLR agonists, in particular a combination of TLR2/6 and TLR9 agonist (e.g., TLR9 oligonucleotide agonist/PAM2CSK4) along with an antigen (e.g., ovalbumin (OVA)) suppresses the immune response as exemplified by the production of antigen-specific IgE and decreases the number of airway eosinophils in bronchoalveolar lavage fluid (BAL) in response to intraperitoneal (IP) immunization with an antigen mixed with alum.