The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2023
Filed:
Feb. 19, 2019
Universidad DE Zaragoza, Saragossa, ES;
Biofabri S.l., Pontevedra, ES;
Carlos Martín Montañes, Saragossa, ES;
Juan Ignacio Aguiló Anento, Saragossa, ES;
Jesús Ángel Gonzalo Asensio, Saragossa, ES;
Dessislava Vaneva Marinova, Saragossa, ES;
Santiago Uganda Maíz, Saragossa, ES;
Esteban Rodríguez Sánchez, Pontevedra, ES;
Eugenia Puentes Colorado, Pontevedra, ES;
Concepción Fernández Álvarez-Santullano, Pontevedra, ES;
UNIVERSIDAD DE ZARAGOZA, Saragossa, ES;
BIOFABRI S.L., Pontevedra, ES;
Abstract
The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to thecomplex, preferably aclinical isolate, more preferablyclinical isolate, characterized in that it comprises a PhoP− phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM− phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection withor those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.