The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2023

Filed:

Mar. 15, 2018
Applicants:

President and Fellows of Harvard College, Cambridge, MA (US);

United Kingdom Research and Innovation, Swindon, GB;

Inventors:

Andrew David Griffiths, Strasbourg, FR;

David A. Weitz, Cambridge, MA (US);

Darren Roy Link, Lexington, MA (US);

Keunho Ahn, Boston, MA (US);

Jerome Bibette, Paris, FR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 33/53 (2006.01); C40B 40/08 (2006.01); B01J 19/00 (2006.01); B01L 3/00 (2006.01); B82Y 10/00 (2011.01); B82Y 30/00 (2011.01); C07K 1/04 (2006.01); C40B 40/10 (2006.01); B01F 25/433 (2022.01); B01F 33/302 (2022.01); B01F 33/3031 (2022.01); B01J 13/02 (2006.01); C40B 40/06 (2006.01); C40B 50/08 (2006.01); G01N 35/10 (2006.01); B01F 23/41 (2022.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C40B 40/08 (2013.01); B01F 25/433 (2022.01); B01F 25/4331 (2022.01); B01F 25/4338 (2022.01); B01F 33/3021 (2022.01); B01F 33/3031 (2022.01); B01J 13/025 (2013.01); B01J 19/0046 (2013.01); B01L 3/5025 (2013.01); B01L 3/5027 (2013.01); B01L 3/502761 (2013.01); B01L 3/502784 (2013.01); B82Y 10/00 (2013.01); B82Y 30/00 (2013.01); C07K 1/047 (2013.01); C40B 40/10 (2013.01); H05K 999/99 (2013.01); B01F 23/41 (2022.01); B01J 2219/005 (2013.01); B01J 2219/0086 (2013.01); B01J 2219/00497 (2013.01); B01J 2219/00576 (2013.01); B01J 2219/00585 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00599 (2013.01); B01J 2219/00707 (2013.01); B01J 2219/00722 (2013.01); B01J 2219/00725 (2013.01); B01J 2219/00743 (2013.01); B01J 2219/00853 (2013.01); B01J 2219/00889 (2013.01); B01L 3/50273 (2013.01); B01L 3/502746 (2013.01); B01L 2200/0605 (2013.01); B01L 2200/0673 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/084 (2013.01); C12N 15/1096 (2013.01); C12Q 2563/159 (2013.01); C12Q 2600/16 (2013.01); C40B 40/06 (2013.01); C40B 50/08 (2013.01); G01N 2035/1034 (2013.01);
Abstract

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.


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