The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2023

Filed:

Nov. 10, 2020
Applicant:

Dionex Corporation, Sunnyvale, CA (US);

Inventors:

Kenneth George Cook, Nothumberland, GB;

Alexander Boris Schwahn, Basel, CH;

Jung Un Baek, San Jose, CA (US);

Shanhua Lin Liehr, Palo Alto, CA (US);

Assignee:

Dionex Corporation, Sunnyvale, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/02 (2006.01); C12N 15/864 (2006.01); C12N 7/00 (2006.01); G01N 30/02 (2006.01); G01N 30/62 (2006.01); C12N 15/86 (2006.01); G01N 30/72 (2006.01); G01N 30/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C12N 7/00 (2013.01); G01N 30/7233 (2013.01); G01N 30/86 (2013.01); G01N 2030/027 (2013.01);
Abstract

A method of separating a liquid sample containing viral vectors includes flowing the liquid sample into an anion exchange column. A first viral vector contains a targeted genetic material and a second viral vector contains essentially no genetic material or a non-targeted genetic material, wherein the targeted genetic material is different than the non-targeted genetic material. A mobile phase can be flowed into the anion exchange column, wherein the mobile phase includes a buffer solution A and a buffer solution B. The buffer solutions A and B both include volatile buffer salts. The first viral vector and the second viral vector can be separated so that the first viral vector and the second viral vector elute off the anion exchange column at different times and then be detected.


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