The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
Dec. 09, 2015
Applicant:
National Research Council of Canada, Ottawa, CA;
Inventors:
Assignee:
National Research Council of Canada, Ottawa, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 11/02 (2006.01); C12N 5/071 (2010.01); C12Q 1/02 (2006.01); C12N 5/073 (2010.01);
U.S. Cl.
CPC ...
C12N 11/02 (2013.01); C12N 5/069 (2013.01); C12N 5/0697 (2013.01); C12Q 1/02 (2013.01); C12N 5/0605 (2013.01); C12N 2502/08 (2013.01); C12N 2502/28 (2013.01); C12N 2503/04 (2013.01); C12N 2506/45 (2013.01);
Abstract
An in vitro population of human brain endothelial cells (hBECs) expressing claudin-5, occludin, ZO-1 and GLUT-1 and expressing one or more of FZD7, WNT7A, WNT7B, APCDD1, STRA6 and ZO-3 is provided. A blood brain barrier (BBB) comprising the hBECs and use of the BBB for analyzing permeability characteristics of a test agent are provided.