The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
Jul. 10, 2020
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Juan Pablo Maianti, Cambridge, MA (US);
David R. Liu, Cambridge, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); C12N 15/10 (2006.01); C07K 14/715 (2006.01); A61P 31/18 (2006.01); C12N 15/113 (2010.01); C12N 9/78 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61P 31/18 (2018.01); C07K 14/7158 (2013.01); C12N 9/78 (2013.01); C12N 15/102 (2013.01); C12N 15/1138 (2013.01); C12Y 305/04001 (2013.01); C07K 2319/80 (2013.01); C12N 2310/20 (2017.05); C12N 2740/16062 (2013.01); C12Y 301/21 (2013.01);
Abstract
Provided herein are systems, compositions, and methods of introducing protective and/or loss-of-function variants of CCR5 and CCR2. Variants may be introduced using a CRISPR/Cas9-based nucleobase editor or other guide nucleotide sequence-programmable DNA binding protein domain-based fusion protein described herein. Further provided herein are compositions and methods of preventing and treating conditions related to HIV infection and progression as well as to AIDS.