The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2023

Filed:

Jun. 02, 2017
Applicant:

Tel Hashomer Medical Research Infrastructure and Services Ltd., Ramat-Gan, IL;

Inventors:

Nicola Maggio, Kiryat-Ono, IL;

Joab Chapman, Kiryat-Ono, IL;

Efrat Shavit Stein, Karkur, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/103 (2006.01); C07K 5/113 (2006.01); C07K 7/06 (2006.01); C07K 14/745 (2006.01); C12N 9/64 (2006.01); C12N 9/74 (2006.01); A61K 38/00 (2006.01); A61P 37/06 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07K 5/1008 (2013.01); A61P 25/00 (2018.01); A61P 29/00 (2018.01); A61P 37/06 (2018.01); C07K 5/1021 (2013.01); C07K 7/06 (2013.01); C07K 14/745 (2013.01); C12N 9/644 (2013.01); C12N 9/6429 (2013.01); C12N 9/6432 (2013.01); C12N 9/6437 (2013.01); C12N 9/6464 (2013.01); A61K 38/00 (2013.01);
Abstract

An isolated peptide of up to 6 amino acids comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR is disclosed. Also disclosed is an isolated peptide comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR, wherein the peptide comprises a modification in at least one amino acid. Also disclosed is a molecule comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR attached to a heterologous moiety. Pharmaceutical compositions and methods of treatment are also disclosed.


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