The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
Jun. 05, 2018
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Deng Pan, Boston, MA (US);
Kai W. Wucherpfennig, Brookline, MA (US);
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); A61K 31/7105 (2006.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); G01N 33/50 (2006.01); A61K 45/06 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61K 31/7105 (2013.01); A61K 38/19 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01); C07K 16/2812 (2013.01); C07K 16/2815 (2013.01); G01N 33/5023 (2013.01); A61K 45/06 (2013.01); A61K 2039/51 (2013.01);
Abstract
The present invention is based, in part, on the identification of biomarkers, and methods of modulate thereof, for sensitizing cancer cells to T cell-mediated killing. For example, the present invention, in part, comprises methods of sensitizing cancer cells in a subject afflicted with a cancer to cytotoxic T cell-mediated killing comprising administering to a subject a therapeutically effective amount of an agent that modulates the biomarker.