The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
Feb. 21, 2020
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Eureka Therapeutics, Inc., Emeryville, CA (US);
Renier J. Brentjens, New York, NY (US);
Eric L. Smith, New York, NY (US);
Cheng Liu, Emeryville, CA (US);
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
EUREKA THERAPEUTICS, INC., Emeryville, CA (US);
Abstract
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor (e.g., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor (e.g., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.