The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
May. 21, 2020
The Regents of the University of California, Oakland, CA (US);
Oak Ridge National Laboratory, Oak Ridge, TN (US);
Zoran Radic, San Diego, CA (US);
Carlo Ballatore, La Jolla, CA (US);
Lukas Gorecki, Hradec Kralovy, CZ;
Palmer Taylor, La Jolla, CA (US);
Andrey Kovalevsky, Oak Ridge, TN (US);
Xiaolin Cheng, Oak Ridge, TN (US);
The Regents of the University of California, Oakland, CA (US);
Oak Ridge National Laboratory, Oak Ridge, TN (US);
Abstract
In alternative embodiments, provided are uncharged bis-oxime antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). In alternative embodiments, provided are pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi-chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound as provided herein.