The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2023
Filed:
Feb. 03, 2021
Applicants:
Rigshospitalet, København, DK;
University of Copenhagen, Copenhagen, DK;
Inventors:
Christoffer Nielsen, Hillerød, DK;
Niels Behrendt, Vaerløse, DK;
Lars Henning Engelholm, Bagsvaerd, DK;
Assignees:
Rigshospitalet, København, DK;
University of Copenhagen, Copenhagen K, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6849 (2017.08); A61K 47/6803 (2017.08); A61K 47/6851 (2017.08); A61K 47/6865 (2017.08); A61P 35/00 (2018.01); C07K 16/28 (2013.01); C07K 16/32 (2013.01);
Abstract
The present invention relates to conjugates targeting uPARAP, in particular antibody-drug conjugates (ADCs) comprising monoclonal antibodies directed against the N-terminal region of uPARAP, and their use in delivery of active agents to cells and tissues expressing uPARAP. The invention further relates to the use of said ADCs in the treatment of diseases involving uPARAP expressing cells, such as cancer.