The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2023

Filed:

Dec. 10, 2021
Applicants:

Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;

Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;

Sorbonne Universite, Paris, FR;

Universite DE Poitiers, Poitiers, FR;

Centre Hospitalier Universitaire DE Poitiers, Poitiers, FR;

Inventors:

Stéphane Bach, Sibiril, FR;

Marie-Thérèse Dimanche-Boitrel, Melesse, FR;

Claire Delehouze, La Roche Maurice, FR;

Thierry Hauet, Mignaloux Beauvoir, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/352 (2006.01); A61P 27/02 (2006.01); A61P 25/00 (2006.01); A61K 45/06 (2006.01); C07D 311/20 (2006.01); C07D 311/54 (2006.01);
U.S. Cl.
CPC ...
A61K 31/352 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01); A61P 27/02 (2018.01); C07D 311/20 (2013.01); C07D 311/54 (2013.01);
Abstract

The present invention relates to a compound of the following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug, particularly intended for inhibiting a programmed cell death route selected from the group consisting of ferroptosis, oxytosis and cellular necroptosis. The present invention also relates to a compound of general formula (I) for use as a drug for neuroprotection as well as for preventing and/or treating disorders associated with cellular necroptosis or ferroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.


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