The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2023

Filed:

May. 11, 2018
Applicant:

The Research Foundation for the State University of New York, Buffalo, NY (US);

Inventors:

Juliane Nguyen, Buffalo, NY (US);

Scott Ferguson, North Tonawanda, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); A61K 9/50 (2006.01); A61K 31/713 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/63 (2013.01); A61K 9/5068 (2013.01); A61K 31/713 (2013.01); C12N 15/111 (2013.01); C12N 2310/141 (2013.01); C12N 2310/20 (2017.05); C12N 2310/3519 (2013.01); C12N 2320/32 (2013.01);
Abstract

Presented are RNA nucleotide sequences referred to as EXO-Codes, and longer RNA polynucleotides that contain the EXO-Codes. EXO-Codes provide RNA with the ability to a) be selectively sorted to extracellular vesicles such as exosomes, and b) deliver a variety of cargo types to program or reprogram the extracellular vesicles, and cells that receive the exosomes. Also presented are methods of making the EXO-Codes, modifying cells using the EXO-Codes, expression vectors encoding the EXO-Codes, and exosomes and other secreted vesicles that include RNA polynucleotides that contain the EXO-Codes.


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