The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2023
Filed:
Jul. 27, 2016
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Dongeun Huh, Villanova, PA (US);
Mark Mondrinos, Philadelphia, PA (US);
Woo Yul Byun, Richland, WA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); A61L 27/18 (2006.01); A61L 27/38 (2006.01); A61L 27/52 (2006.01); A61L 27/50 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); C08L 83/04 (2006.01); C12N 5/00 (2006.01); G01N 33/50 (2006.01); G09B 23/30 (2006.01); C12M 3/06 (2006.01);
U.S. Cl.
CPC ...
C12M 21/08 (2013.01); A61L 27/18 (2013.01); A61L 27/22 (2013.01); A61L 27/3633 (2013.01); A61L 27/3804 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); C08L 83/04 (2013.01); C12M 3/00 (2013.01); C12M 23/16 (2013.01); C12M 23/20 (2013.01); C12M 25/02 (2013.01); C12M 25/14 (2013.01); C12M 29/10 (2013.01); C12N 5/0018 (2013.01); C12N 5/0062 (2013.01); C12N 5/0068 (2013.01); G01N 33/5005 (2013.01); G01N 33/5044 (2013.01); G09B 23/30 (2013.01); G09B 23/306 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01); C12N 2535/00 (2013.01); C12N 2537/10 (2013.01);
Abstract
The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.