The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2023
Filed:
Mar. 10, 2020
Five Prime Therapeutics, Inc., South San Francisco, CA (US);
Charles Kaplan, San Francisco, CA (US);
Derrick Houser, San Francisco, CA (US);
Luis Borges, San Mateo, CA (US);
Gloria Brattich, San Francisco, CA (US);
David Bellovin, San Jose, CA (US);
Felicia Kemp, San Jose, CA (US);
Majid Ghoddusi, Walnut Creek, CA (US);
Nels P. Nielson, Lebanon, NH (US);
Kathy Miller, San Francisco, CA (US);
Maike Schmidt, San Francisco, CA (US);
FIVE PRIME THERAPEUTICS, INC., South San Francisco, CA (US);
Abstract
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.