The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2023

Filed:

Dec. 02, 2021
Applicants:

Academia Sinica, Taipei, TW;

National Yang Ming Chiao Tung University, Taipei, TW;

Inventors:

Ruey-Hwa Chen, Taipei, TW;

Yu-Hsuan Chen, Taipei, TW;

Tzu-Yu Huang, Taipei, TW;

Wen-Hsin Li, Taipei, TW;

Ting-Fen Tsai, Taipei, TW;

Zhao-Qing Shen, Taipei, TW;

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61P 3/00 (2006.01); C12N 15/86 (2006.01); A61K 38/48 (2006.01); A61P 3/04 (2006.01); A61K 45/06 (2006.01); C12N 9/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4813 (2013.01); A61K 45/06 (2013.01); A61P 3/04 (2018.01); C12N 9/485 (2013.01); C12N 15/86 (2013.01); C12Y 304/19012 (2013.01); C12N 2750/14111 (2013.01);
Abstract

Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.


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