The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2023

Filed:

Mar. 12, 2021
Applicant:

Novartis Ag, Basel, CH;

Inventors:

Karin Briner, Cambridge, MA (US);

Brian Addison Dechristopher, Belmont, MA (US);

Alec Nathanson Flyer, Cambridge, MA (US);

Andrei Alexandrovich Golosov, Cambridge, MA (US);

Philipp Grosche, Inzlingen, DE;

Eugene Yuejin Liu, Lexington, MA (US);

Justin Yik Ching Mao, North Reading, MA (US);

Lauren Gilchrist Monovich, Belmont, MA (US);

Tajesh Jayprakash Patel, Westford, MA (US);

Liansheng Su, Winchester, MA (US);

Lihua Yang, Westford, MA (US);

Rui Zheng, Needham, MA (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 45/06 (2006.01); C07K 5/12 (2006.01);
U.S. Cl.
CPC ...
A61K 38/12 (2013.01); A61K 45/06 (2013.01); C07K 5/126 (2013.01);
Abstract

The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R, R, R, R, R, R, R, R, R, X, X, and Xare described herein.


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