The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2023
Filed:
Jul. 30, 2020
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Srikanth Singamaneni, St. Louis, MO (US);
Zheyu Wang, St. Louis, MO (US);
Jingyi Luan, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/145 (2006.01); A61M 37/00 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); G01N 33/53 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61B 5/14514 (2013.01); A61K 9/0021 (2013.01); A61M 37/0015 (2013.01); G01N 33/5306 (2013.01); G01N 33/54386 (2013.01); G01N 33/6869 (2013.01); A61M 2037/0061 (2013.01);
Abstract
The present disclosure is directed to microneedle patches for direct sampling and ultrasensitive detection of protein biomarkers in dermal interstitial fluids. The microneedle patches are comprised of polymers with high protein absorption capability (e.g. polystyrene) and are modified with capture biorecognition elements that are specific to target analytes in the interstitial fluid (ISF). Systems and methods are further provided for detection of a target ISF analyte obtained by in vivo sampling of the ISF using a microneedle patch.