The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2023
Filed:
Oct. 25, 2021
Applicant:
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Inventors:
Xiangxu Kong, Union City, CA (US);
Gene Shen, Santa Clara, CA (US);
Assignee:
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6869 (2018.01); C07H 19/207 (2006.01); G01N 33/542 (2006.01); G01N 33/58 (2006.01); G01N 21/64 (2006.01); C12Q 1/6818 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6869 (2013.01); C07H 19/207 (2013.01); C12Q 1/6818 (2013.01); G01N 21/6428 (2013.01); G01N 33/542 (2013.01); G01N 33/582 (2013.01); G01N 2021/6441 (2013.01); Y10T 436/143333 (2015.01);
Abstract
Reaction mixtures are provided having at least a first nucleotide analog and a second nucleotide analog that produce signals in response to excitation illumination. The signals produced by the analogs have peaks at the same wavelengths, but have distinct signal intensities. The distinct intensities allow for identification of the analogs in nucleic acid sequencing. In some embodiments, FRET-labeled compounds are provided. In certain embodiments, FRET-labeled nucleotide analogs are used, for example, in DNA sequencing or RNA sequencing.