The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2023
Filed:
Oct. 06, 2022
Applicant:
4d Molecular Therapeutics Inc., Emeryville, CA (US);
Inventors:
Melissa Kotterman, Emeryville, CA (US);
Peter Francis, Emeryville, CA (US);
Melissa Calton, Emeryville, CA (US);
Johnny Gonzales, Emeryville, CA (US);
Roxanne Croze, Emeryville, CA (US);
Christopher Schmitt, Emeryville, CA (US);
Assignee:
4D Molecular Therapeutics Inc., Emeryville, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/005 (2006.01); A61K 9/12 (2006.01); A61K 9/00 (2006.01); C07K 14/47 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 9/0078 (2013.01); A61K 9/12 (2013.01); A61P 11/00 (2018.01); C07K 14/005 (2013.01); C07K 14/4712 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01);
Abstract
The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.