The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2023

Filed:

Aug. 08, 2022
Applicants:

Jiangnan University, Jiangsu, CN;

Shandong Focusfreda Biotech Co., Ltd, Shandong, CN;

Inventors:

Jinsong Shi, Jiangsu, CN;

Zhenghong Xu, Jiangsu, CN;

Jinsong Gong, Jiangsu, CN;

Wei Liu, Jiangsu, CN;

Hui Li, Jiangsu, CN;

Jianying Qian, Jiangsu, CN;

Lei Liu, Shandong, CN;

Qing Li, Shandong, CN;

Mengyi Zhang, Shandong, CN;

Chuanli Kang, Shandong, CN;

Assignee:

JIANGNAN UNIVERSITY, Jiangsu, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12R 1/01 (2006.01);
U.S. Cl.
CPC ...
C12N 1/20 (2013.01); C12N 1/205 (2021.05); C12R 2001/01 (2021.05); C12Y 302/01036 (2013.01);
Abstract

The invention belongs to the field of cosmetic biotechnology, and specifically relates to anthat degrades hyaluronic acid and a cultivation method and application thereof. Thesp. CGJ001 of the present invention was deposited in the China General Microbiological Culture Collection Center on Oct. 10, 2019, and the preservation number is CGMCC NO. 18661. Thestrain can efficiently produce hyaluronidase, and can be used in the process of preparing low molecular hyaluronic acid and oligomeric hyaluronic acid from high molecular hyaluronic acid. The enzyme has high specificity towards hyaluronic acid, excellent thermal stability and pH stability, and is suitable for large-scale industrial application. Thus, it can replace the traditional hyaluronidase extracted from expensive animal tissues. There should be broad application prospects in the fields of medicine and cosmetics.


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