The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2023
Filed:
Jan. 28, 2021
Amgen Inc., Thousand Oaks, CA (US);
Jerry Ryan Holder, Simi Valley, CA (US);
Gayathri Swaminath, Brisbane, CA (US);
Michael J. Frohn, Thousand Oaks, CA (US);
Brian Alan Lanman, Woodland Hills, WA (US);
Anthony B. Reed, Newbury Park, CA (US);
Leslie P. Miranda, Thousand Oaks, CA (US);
John Gordon Allen, Newbury Park, CA (US);
Alexander J. Pickrell, Westlake Village, CA (US);
Aaron C. Siegmund, Ventura, CA (US);
Lewis D. Pennington, Arlington, MA (US);
Bryant Yang, Agoura Hills, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.