The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2023

Filed:

Nov. 30, 2018
Applicant:

Arrakis Therapeutics, Inc., Waltham, MA (US);

Inventors:

Gnanasambandam Kumaravel, Lexington, MA (US);

Jennifer C. Petter, Stow, MA (US);

Jonathan Craig Blain, Melrose, MA (US);

Donovan Noel Chin, Lexington, MA (US);

Chao Fang, Lexington, MA (US);

Herschel Mukherjee, Somerville, MA (US);

Neil Kubica, Swampscott, MA (US);

Assignee:

Arrakis Therapeutics, Inc., Waltham, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07D 401/14 (2006.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); A61K 9/00 (2006.01); C07D 495/04 (2006.01); C12N 15/115 (2010.01); G01N 33/50 (2006.01); C07D 401/12 (2006.01); A61K 31/522 (2006.01); A61K 39/395 (2006.01); C12Q 1/6816 (2018.01); A61K 31/65 (2006.01); C07D 217/26 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/522 (2013.01); A61K 31/65 (2013.01); A61K 39/395 (2013.01); A61K 47/545 (2017.08); A61K 47/6809 (2017.08); A61P 25/28 (2018.01); A61P 43/00 (2018.01); C07D 217/26 (2013.01); C07D 401/12 (2013.01); C07D 495/04 (2013.01); C12N 15/115 (2013.01); C12Q 1/6816 (2013.01); G01N 33/5008 (2013.01);
Abstract

The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.


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