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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11807606 B1

PDFFull Text
Date of Patent:
Nov. 07, 2023

Filed:

Jan. 24, 2019

Sulfonamide derivatives for protein degradation

Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Nathanael S. Gray, Boston, MA (US);

Eric Fischer, Chestnut Hill, MA (US);

Hojong Yoon, Cambridge, MA (US);

Tinghu Zhang, Brookline, MA (US);

Tyler Faust, Brookline, MA (US);

Katherine Donovan, Boston, MA (US);

Quan Cai, Shanghai, CN;

Zhengnian Li, Newton, MA (US);

Assignee:

DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);

Attorneys:

BURNS & LEVINSON, LLP

Daniel W. Clarke

Shawn P. Foley

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 209/08 (2006.01); C07D 231/56 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 209/08 (2013.01); C07D 231/56 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

DCAF15 is a substrate recognition (adaptor) protein of E3 ubiquitin ligase. Disclosed herein are compounds that recruit ubiquitin ligase CRL4, to a target RNA recognition motif (RRM), causing its degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

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Gray, Nathanael. (2023). Sulfonamide derivatives for protein degradation (U.S. Patent No. 11807606). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11807606

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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