The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2023

Filed:

May. 14, 2021
Applicants:

Musc Foundation for Research Development, Charleston, SC (US);

United States Government As Represented BY the Department of Veteran Affairs, Washington, DC (US);

Inventors:

Stephen Tomlinson, Charleston, SC (US);

DeAnna Adkins, Charleston, SC (US);

Ali Alawieh, Charleston, SC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/57 (2006.01); C07K 16/18 (2006.01); A61K 38/17 (2006.01); A61K 38/49 (2006.01); A61P 25/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/57 (2013.01); A61K 38/1709 (2013.01); A61K 38/1725 (2013.01); A61K 38/49 (2013.01); A61P 25/00 (2018.01); C07K 16/18 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01);
Abstract

The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.


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