The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2023
Filed:
May. 19, 2023
Applicant:
Radius Health, Inc., Boston, MA (US);
Inventors:
Matt Burke, Wayne, PA (US);
Silvio Campagna, Lehigh Acres, FL (US);
Assignee:
Radius Health, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/06 (2006.01); C07K 14/635 (2006.01); A61K 38/29 (2006.01); C07K 1/04 (2006.01); C07K 1/08 (2006.01);
U.S. Cl.
CPC ...
A61K 38/29 (2013.01); C07K 1/066 (2013.01); C07K 14/635 (2013.01); C07K 1/04 (2013.01); C07K 1/06 (2013.01); C07K 1/084 (2013.01);
Abstract
Disclosed herein is an improved process for preparing abaloparatide. The process generally utilizes solid phase peptide synthesis employing an Fmoc-protection scheme. Incorporating a systematic recoupling step of a glutamine residue (Gln) has been found to minimize the formation of an undesirable des-Glnabaloparatide impurity, which is often obtained in significant quantities in the conventional process.