The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2023

Filed:

Mar. 31, 2021
Applicant:

Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts, Heidelberg, DE;

Inventors:

Mathias Heikenwälder, Heidelberg, DE;

Lars Zender, Rottenburg, DE;

Achim Weber, Zürich, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 31/7105 (2006.01); A61P 1/16 (2006.01); A61K 9/00 (2006.01); A61K 31/192 (2006.01); A61K 31/405 (2006.01); A61K 31/616 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/00 (2013.01); A61K 31/192 (2013.01); A61K 31/405 (2013.01); A61K 31/616 (2013.01); A61K 31/713 (2013.01); A61P 1/16 (2018.01); C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/20 (2017.05);
Abstract

The present invention provides novel compounds that target thrombocyte activity or aggregation capacity through cellular components for the treatment of diseases associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The invention provides these compounds for treating non-alcoholic steatohepatitis (NASH), a progressed stage of NAFL (non-alcoholic fatty liver), in order to avoid the development of liver cirrhosis and Hepatocellular Carcinoma (HCC). Further provided are pharmaceutical compositions, comprising the compounds of the invention, and methods for screening new NASH therapeuticals.


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