The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Aug. 04, 2017
Applicant:
Arizona Board of Regents on Behalf of Arizona State University, Scottsdale, AZ (US);
Inventors:
Alexander Green, Scottsdale, AZ (US);
Duo Ma, Tempe, AZ (US);
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, Scottsdale, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6897 (2018.01); C12Q 1/70 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2018.01); C12N 15/67 (2006.01); C12N 15/63 (2006.01); C12Q 1/6809 (2018.01); C12Q 1/6816 (2018.01); C12Q 1/689 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6897 (2013.01); C12N 15/113 (2013.01); C12N 15/63 (2013.01); C12N 15/67 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/689 (2013.01); C12Q 1/6816 (2013.01); C12Q 1/70 (2013.01); C12N 2310/531 (2013.01);
Abstract
Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.