The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Jan. 04, 2019
Ottawa Hospital Research Institute, Ottawa, CA;
Turnstone Biologics Corp., La Jolla, CA (US);
John C. Bell, Ottawa, CA;
Fabrice Le Boeuf, Gatineau, CA;
Michael S. Huh, Gatineau, CA;
Matthew Y. Tang, Orleans, CA;
Adrian Pelin, Ottawa, CA;
Brian Andrew Keller, Ottawa, CA;
Caroline J. Breitbach, Somerville, MA (US);
Michael F. Burgess, Chester, NJ (US);
Steven H. Bernstein, Lawrenceville, NJ (US);
OTTAWA HOSPITAL RESEARCH INSTITUTE, Ottawa, CA;
TURNSTONE BIOLOGICS CORP., La Jolla, CA (US);
Abstract
The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.