The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Aug. 06, 2015
Tufts University, Medford, MA (US);
University of Pavia, Pavia, IT;
Alessandra Balduini, Pavia, IT;
David L. Kaplan, Concord, MA (US);
Lindsay Wray, Fairfield, CA (US);
Christian Andrea Di Buduo, Pavia, IT;
Lorenzo Tozzi, Pavia, IT;
Tufts University, Medford, MA (US);
University of Pavia, Pavia, IT;
Abstract
The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 μm and 100 μm thick, inclusive, contacting the silk membrane with a porogen to form a porous silk membrane comprising at least one silk wall defining a lumen, associating the porous silk membrane with stromal derived factor-1? and at least one functionalizing agent, forming a three dimensional silk matrix comprising interconnected pores wherein the pores have a diameter of between about 5 and 500 μm, inclusive, wherein the silk matrix is formed around at least a portion of the porous silk membrane, introducing a plurality of megakaryocytes to the silk matrix such that the megakaryocytes are located at least partially within the porous silk matrix, and stimulating the plurality of megakaryocytes to produce platelets. Also provided are various new compositions and methods of making those compositions.