The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2023
Filed:
Oct. 20, 2020
Applicant:
Nanjing Leads Biolabs Co., Ltd., Jiangsu, CN;
Inventors:
Xiaoqiang Kang, Plainsboro, NJ (US);
Xiao Huang, Jiangsu, CN;
Assignee:
Nanjing Leads Biolabs Co., Ltd., Nanjing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 16/28 (2006.01); C07K 14/71 (2006.01); A61P 35/00 (2006.01); C12N 5/10 (2006.01); C12N 15/63 (2006.01); A61K 31/713 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70596 (2013.01); A61K 31/713 (2013.01); A61P 35/00 (2018.01); C07K 14/71 (2013.01); C07K 16/2818 (2013.01); C12N 5/10 (2013.01); C12N 15/63 (2013.01); A61K 2039/505 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/32 (2013.01); C07K 2319/33 (2013.01);
Abstract
A recombinant fusion protein comprising 1) TGFβR2, or a fragment thereof, capable of binding to TGFβ, and 2) an antibody, or an antigen-binding fragment thereof, that binds to PD-1. Also disclosed are a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over expression of TGFβ and/or PD-1 using the recombinant protein.